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أريد مصادر أو مراجع عن : Calcium glucose transport and insulin action؟


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Calcium glucose transport and insulin action

In insulin-sensitive cells, the glucose transport system serves the purpose of controlling the access of glucose to the cytoplasm. Like the other rate-limiting processes along the cellular metabolic pathways, the transport of glucose seems to be stimulated by either endogenous or exogenous factors

For instance, we know that when the need for metabolizable substrate is increased during anoxia or contractile activity, the uptake of glucose is increased. It seems likely that this is the result of an activation of the glucose transport system brought about by endogenous factors, i.e. agents generated inside the cell following the metabolic perturbation

 The very same agents may be of importance for the activation induced by exogenous factors like insulin or other hormones

If this is the case, it might even be possible to identify one common denominator for all the many conditions and factors which are known to stimulate glucose transport - a compound which in ideally all of these instances is made available at the plasma membrane and which can be shown to induce direct activation of the glucose transport system

Ten years ago, Holloszy and Narahara (1965) proposed that the Ca2+ ion might be an important activator for the glucose transport system. This possibility may be tested by examining the consequences of exposing the glucose transport system to calcium

Important Sources/ references to get This topic

Biochemistry of Membrane Transport book.pdf

Ca+2 fluxes and insulin action in cardiac and skeletal muscles

Calcium, Glucose Transport and Insulin Action

Harpers illustrated biochemistry 28th ed



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سُئل يونيو 27، 2020 في تصنيف الكيمياء الحيوية بواسطة aml
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